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Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: protective ability of host defense system is largely dependent on germ-line encoded pattern-recognition receptorsThe most studied PRRs are Toll-like receptors (TLRs).

Keywords： Toll-like receptors     innate immunity     infectious disease     inflammation    

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Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 292-301 doi: 10.1007/s11684-020-0806-5

Abstract: The high- and the low-molecular weight hyaluronic acids (HMW-HA and LMW-HA, respectively) showed different biological activities in inflammation. However, the role of LMW-HA in inflammatory response is controversial. In this study, we aimed to investigate the effect of bioactive hyaluronan (B-HA) on lipopolysaccharide (LPS)-induced inflammatory responses in human macrophages and mice. B-HA was produced from HA treated with glycosylated recombinant human hyaluronidase PH20. Human THP-1 cells were induced to differentiate into macrophages. THP-1-derived macrophages were treated with B-HA, LPS, or B-HA+LPS. The mRNA expression and the production of inflammatory cytokines were determined using quantitative real-time PCR and enzyme-linked immunosorbent assay. The phosphorylation levels of proteins in the nuclear factor- B (NF- B), mitogen-activated protein kinase (MAPK), and IRF-3 signaling pathways were measured using Western blot. The efficacy of B-HA was assessed in a mouse model of LPS-induced inflammation. Results showed that B-HA inhibited the expression of TNF-α, IL-6, IL-1, and IFN-β, and enhanced the expression of the anti-inflammatory cytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and . B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65, IKKα/β, I Bα, JNK1/2, ERK1/2, p38, and IRF-3. In conclusion, our results demonstrated that the B-HA attenuated the LPS-stimulated inflammatory response by inhibiting the activation of the TLR4 signaling pathway. B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease.

Keywords： bioactive hyaluronan     lipopolysaccharide     inflammatory cytokines     TLR4     human macrophages    

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Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 288-303 doi: 10.1007/s11684-015-0412-0

Abstract:

Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid

Keywords： TLR     MyD88     hematopoiesis     bone marrow failure     leukemia     myelodysplastic syndrome    

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Group III metabotropic glutamate receptors and drug addiction

Limin Mao, Minglei Guo, Daozhong Jin, Bing Xue, John Q. Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 445-451 doi: 10.1007/s11684-013-0291-1

Abstract: Accumulating data have demonstrated roles of ionotropic glutamate receptors and group I and II metabotropicglutamate receptors (mGluRs) in this event.These presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain

Keywords： group III metabotropic glutamate receptors     cocaine     amphetamine     alcohol     opiate    

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Expression of protease-activated receptors on platelets in healthy individuals

Rui ZHU, Lin SHEN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 236-239 doi: 10.1007/s11684-009-0040-7

Abstract: This study aimed to investigate the expression of protease-activated receptors (PARs) on platelets in

Keywords： protease-activated receptors     platelet    

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Implementation of a flexible Major Vacation Toll-free Program for small passenger vehicles in China

Meng XU, Ziyou GAO

Frontiers of Engineering Management 2017, Volume 4, Issue 4,   Pages 498-499 doi: 10.15302/J-FEM-2017111

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy. However, the good efficacy of CATs is rarely reported in clinical applications because CATs have no or very low antigen specificity. The low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT). Herein, we demonstrate that NY-ESO-1157–165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cells with good efficacy. With low micromolar range dissociation equilibrium constants, HAT-transduced CATs showed good specificity with no off-target killing. Furthermore, the high-affinity TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered T cells (TCR-Ts) in terms of interferon-g and granzyme B production and in vitro cancer cell killing ability. TCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy.

Keywords： cytokine-activated T cells     high-affinity T cell receptor     cancer immunotherapy     TCR-CAT    

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Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 465-472 doi: 10.1007/s11684-016-0482-7

Abstract: However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remainthe roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors

Keywords： electroacupuncture     analgesia     ASIC3     TRPV1     C-fiber reflex    

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: 26 gliomas, we reported their classification into primitive oligodendrocyte precursor cell (pri-OPC)-likeand radial glia (RG)-like tumors and validated it in a public cohort and TCGA glioma., and the pri-OPC-like ones were prone to carrying TP53 mutations.For example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptorsIGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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Self-sacrificial templating synthesis of flower-like nickel phyllosilicates and its application as high-performance

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 484-497 doi: 10.1007/s11705-021-2074-6

Abstract: The nanocomposites of flower-like nickel phyllosilicate particles incorporated into epoxy resin wereThe flower-like nickel phyllosilicate particles were firstly synthesized using a mild self-sacrificialIt was demonstrated that adequate flower-like nickel phyllosilicate particles dispersed well in the matrixNevertheless, the incorporated flower-like nickel phyllosilicate particles resulted in the continuouslyThis study revealed the giant potential of flower-like particles in preparing high-quality EP nanocomposites

Keywords： nickel phyllosilicate     flow-like structure     mechanical property     thermal stability     tribological performance    

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Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3,   Pages 30-43 doi: 10.1016/j.eng.2021.10.018

Abstract:

Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionizedCells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific

Keywords： Chimeric antigen receptors     T cell     Treg     Alloimmunity     Bioengineering     Transplant     Autoimmunity    

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Dispersion of “guava-like” silica/polyacrylate nanocomposite particles in polyacrylate matrix

QI Dongming, YANG Lei, WU Minghua, SHAO Jianzhong, BAO Yongzhong

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 127-134 doi: 10.1007/s11705-008-0033-0

Abstract: A series of “guava-like” silica/polyacrylate nanocomposite particles with close silica content and differentpolyacrylate molded composites and the dispersion mechanism of these silica particles from the “guava-likepolyacrylate onto silica was in a moderate range (ca. 20%–70%), almost all of silica particles in these “guava-like

Keywords： silica/polyacrylate composite     cross-linked network     –70     guava-like     TEM    

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Layer-like FAU-type zeolites: A comparative view on different preparation routes

Bastian Reiprich, Tobias Weissenberger, Wilhelm Schwieger, Alexandra Inayat

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 2,   Pages 127-142 doi: 10.1007/s11705-019-1883-3

Abstract: The creation of intergrown layer-like zeolite crystals is one route to form hierarchical zeolites.systems in FAU, we will review the currently existing strategies for the synthesis of FAU with layer-likeHowever, a very recent approach is the synthesis of layer-like FAU-type zeolite crystals assembled inThis additive-free preparation route for layer-like FAU, which appears very attractive from an ecologicalmicroscopy, nitrogen physisorption and elemental analysis, between conventional FAU and three layer-like

Keywords： FAU     hierarchical zeolite     layer-like morphology    

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Synthesis and characterization of well-defined comb-like branched polymers

LI Aixiang, LU Zaijun, LÜ Zijian

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 4,   Pages 407-411 doi: 10.1007/s11705-008-0064-6

Abstract: Well-defined comb-like branched polymers having one branch in each repeating unit have been successfullyThe resulting comb-like branched polymers were characterized by IR, H-NMR, gel permeation chromatography

Keywords： grafting efficiency     polyisoprene     quantitative grafting     effective     molecular    

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Novel synthetic approaches and TWC catalytic performance of flower-like Pt/CeO

Zongcheng ZHAN,Xiaojun LIU,Dongzhu MA,Liyun SONG,Jinzhou LI,Hong HE,Hongxing DAI

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 4,   Pages 483-495 doi: 10.1007/s11783-013-0595-z

Abstract: novel Ultrasonic Assisted Membrane Reduction (UAMR)-hydrothermal method was used to prepare flower-likeThe texture, physical/chemical properties, and reducibility of the flower-like Pt/CeO catalysts wereIn brief, the flower-like Pt/CeO catalysts prepared by UAMR-hydrothermal method exhibited a higher Pt

Keywords： three-way catalyst     flower-like     Ultrasonic Assisted Membrane Reduction (UAMR)     Pt nanoparticles    

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Title Author Date Type Operation

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Journal Article

Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Journal Article

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Journal Article

Group III metabotropic glutamate receptors and drug addiction

Limin Mao, Minglei Guo, Daozhong Jin, Bing Xue, John Q. Wang

Journal Article

Expression of protease-activated receptors on platelets in healthy individuals

Rui ZHU, Lin SHEN

Journal Article

Implementation of a flexible Major Vacation Toll-free Program for small passenger vehicles in China

Meng XU, Ziyou GAO

Journal Article

High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Journal Article

Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

Self-sacrificial templating synthesis of flower-like nickel phyllosilicates and its application as high-performance

Journal Article

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Journal Article

Dispersion of “guava-like” silica/polyacrylate nanocomposite particles in polyacrylate matrix

QI Dongming, YANG Lei, WU Minghua, SHAO Jianzhong, BAO Yongzhong

Journal Article

Layer-like FAU-type zeolites: A comparative view on different preparation routes

Bastian Reiprich, Tobias Weissenberger, Wilhelm Schwieger, Alexandra Inayat

Journal Article

Synthesis and characterization of well-defined comb-like branched polymers

LI Aixiang, LU Zaijun, LÜ Zijian

Journal Article

Novel synthetic approaches and TWC catalytic performance of flower-like Pt/CeO

Zongcheng ZHAN,Xiaojun LIU,Dongzhu MA,Liyun SONG,Jinzhou LI,Hong HE,Hongxing DAI

Journal Article